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Traditionally, it has been thought that schizophrenia results from the interaction of predisposing genes and hazardous environmental factors. In this article, the paradigm of "genes plus environment" is challenged, and a new interpretation is presented, in which the emphasis on DNA sequence variation is shared with epigenetic misregulation as a critical etiopathogenic factor. Partial epigenetic stability metastability of gene regulation is consistent with various nonmendelian irregularities of schizophrenia, such as the presence of clinically indistinguishable sporadic and familial cases, discordance of monozygotic twins, coincidence of peaks of susceptibility with major endocrine rearrangements, and fluctuating course of disease severity, among others. It is also suggested that stochastic epigenetic events might account for a substantial portion of phenotypic variance, which traditionally has been ascribed to environmental effects.
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It therefore has the same objective: make scientific documents available to scientists all around the world, rapidly and freely, but with a restriction to PHD thesis and habilitations HDR, in countries where habilitations exist. CCSD does not make any scientific evaluation of the thesis that are submitted, since this is the responsibiliy of the university professors in the examination board. There are nearly 10 million bibliographic records in this catalogue describing all kinds of document books, dissertations, reviews, electronic resources, audio-visual documents, microfiches, maps, scores, manuscripts and very old books. DART-Europe is a partnership of research libraries and library consortia who are working together to improve global access to European research theses. Find online or print thesis.
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A thesis or dissertation [note 1] abbreviated diss. The required complexity or quality of research of a thesis or dissertation can vary by country, university, or program, and the required minimum study period may thus vary significantly in duration. The word "dissertation" can at times be used to describe a treatise without relation to obtaining an academic degree.

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